Tenofovir
[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid
(R)-9-(2-phosphonylmethoxypropyl)adenine
PMPA
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| NU-974 | 100 mg | Sob demanda | Adicionar ao Carrinho |
![Structural formula of Tenofovir ([(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethylphosphonic acid)](/images/Structures/NU-974.png)
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C9H14N5O4P (free acid)
Peso molecular: 287.21 g/mol (free acid)
CAS#: 147127-20-6
Pureza: ≥ 98 % (HPLC)
Forma: solid
Propriedades espectroscópicas: λmax 259 nm, ε 15.4 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Referências selecionadas:
Krejčová et al. (2000) Phosphorylation of Purine (Phosphonomethoxy)alkyl Derivatives by Mitochondrial AMP Kinase (AK2 Type) from L1210 Cells. Collect. Czech. Chem. Commun. 65:1653.
Robbins et al. (1998) Anti-human immunodeficiency virus activity and cellular metabolism of a potential prodrug of the acyclic nucleoside phosphonate 9-R-(2-phosphonomethoxypropyl)adenine (PMPA), Bis(isopropyloxymethylcarbonyl)PMPA. Antimicrob. Agents Chemother. 42(3):612.
Robbins et al. (1995) Metabolic Pathways for Activation of the Antiviral Agent 9-(2-Phosphonylmethoxyethyl)Adenine in Human Lymphoid Cells. Antimicrob. Agents Chemother. 39(10):2304.