Nucleotídeos Antivirais
Table 2: Antiviral properties of selected nucleotide analogs.
| Nucleotide | Analog of... | Incorporation by viral... | Mechanism of inhibition |
|---|---|---|---|
| Lamivudine triphosphate | ...Cytidine triphosphate | ...Reverse Transcriptase[1] | Chain termination of viral cDNA synthesis |
| Stavudine triphosphate | ...Thymidine triphosphate | ...Reverse Transcriptase[2] | Chain termination of viral cDNA synthesis |
| Zidoduvine triphosphate | ...Thymidine triphosphate | ...Reverse Transcriptase[3] | Chain termination of viral cDNA synthesis |
| Aciclovir triphosphate | ...Guanosine triphosphate | ...DNA polymerase[4] | Chain termination of viral DNA synthesis[4] |
| Vidarabine triphosphate | ...Adenosine triphosphate | ...DNA polymerase[5] | unknown |
| Ribavirin triphosphate | ...Guanosine triphosphate | ...RNA polymerase[6] | Mutagenesis of viral genome replication[6] |
Produtos
Selected References
1] Huang at al. (2011) Effect of reverse transcriptase inhibitors on Line-1 and Ty1 reverse transcriptase activities and on LINE-1 retrotransposition. BMC Biochemistry 12:18.
[2] Vaccaro at al. (1999) Mechanism of Inhibition of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase by d4TTP: an Equivalent Incorporation Efficiency Relative to the Natural Substrate dTTP. Antimicrob. Agents Chemother. 44 (1):217.
[3] Jaju at al. (1995) Human immunodeficiency virus type 1 reverse transcriptase. 3'-Azidodeoxythymidine 5'-triphosphate inhibition indicates two-step binding for template-primer. J. Biol. Chem. 270 (17):9740.
[4] Furmann at al. (1979) Inhibition of Herpes Simplex Virus-Induced DNA Polymerase Activity and Viral DNA Replication by 9-(2-Hydroxyethoxymethyl)guanine and Its Triphosphate. J. Virol. 29 (2):154.
[5] Muller at al. (1977) Inhibition of Herpesvirus DNA synthesis by 9-O-D-Arabinofuranosyladenine in cellular and cell-free systems. Ann. N.Y. Acad. Sci. 284:34.
[6] Crotty at al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nature Medicine 6 (12):1375.
[7] Ray at al. (2009) Metabolism of antiviral nucleosides and nucleotides. In: Antiviral Research: Strategies in antiviral drug discovery (LaFemina). ASM Press.
[8] Simons at al. (2005) Recent Advances in Antiviral Nucleoside and Nucleotide Therapeutics. Current Topics in Medicinal Chemistry 5:1191.