d4TTP
Stavudine triphosphate, Sodium Salt
2',3'-Didehydro-2',3'-dideoxythymidine-5'-triphosphate, Sodium salt
| Catálogo Nº | Apresentação | Preço (R$) | Comprar |
|---|---|---|---|
| NU-1604S | 10 μl (100 mM) | Sob demanda | Adicionar ao Carrinho |
| NU-1604L | 5 x 10 μl (100 mM) | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C10H15N2O13P3 (free acid)
Peso molecular: 464.15 g/mol (free acid)
CAS#: 611-60-9
Pureza: ≥ 95 % (HPLC)
Forma: solution in water
Concentração: 100 mM - 110 mM
pH: 7.5 ±0.5
Propriedades espectroscópicas: λmax 266 nm, ε 10.1 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Referências selecionadas:
Coulier et al. (2008) Simultaneous determination of endogenous deoxynucleotides and phosphorylated nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cells using ion-pair liquid chromatography coupled to mass spectrometry. Proteomics Clin. Appl. 2:1557.
Ray et al. (2002) Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate. Biochemistry 41:5150.
Hoggard et al. (2000) Correlation between intracellular pharmacological activation of nucleoside analogues and HIV suppression in vitro. Antivir. Chem. Chemother. 11:353.
Vaccaro et al. (2000) Mechanism of inhibition of the human immunodeficiency virus type 1 reverse transcriptase by d4TTP: an equivalent incorporation efficiency relative to the natural substrate dTTP. Antimicrob. Agents. Chemother. 44:217.
Ueno et al. (1997) Comparative enzymatic study of HIV-1 reverse transcriptase resistant to 2',3'-dideoxynucleotide analogs using the single-nucleotide incorporation assay. Biochemistry 36:1092.
Im et al. (1993) Identification of the amino acid in the human immunodeficiency virus type 1 reverse transcriptase involved in the pyrophosphate binding of antiviral nucleoside triphosphate analogs and phosphonoformate. Implications for multiple drug resistance. Biochem. Pharmacol. 46:2307.
Huang et al. (1992) Selective action of 2',3'-didehydro-2',3'-dideoxythymidine triphosphate on human immunodeficiency virus reverse transcriptase and human DNA polymerases. J. Biol. Chem. 267:2817.