Ribavirin-triphosphate
Sodium Salt
1-β-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide-5'-triphosphate, Sodium salt
| Catálogo Nº | Apresentação | Preço (R$) | Comprar |
|---|---|---|---|
| NU-1105S | 20 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
| NU-1105L | 5 x 20 μl (10 mM) | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C8H15N4O14P3 (free acid)
Peso molecular: 484.14 g/mol (free acid)
CAS#: 63142-71-2
Pureza: ≥ 95 % (HPLC)
Forma: solution in water
Concentração: 10 mM - 11 mM
pH: 7.5 ±0.5
Propriedades espectroscópicas: λmax 230 nm, ε 3.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Referências selecionadas:
Kiso et al. (2010) T-705 (favipiravir) activity against lethal H5N1 influenza A viruses. Proc. Natl. Acad. Sci. USA. 107 (2):882.Maag et al. (2001) Hepatitis C virus RNA-dependent RNA polymerase (NS5B) as a mediator of the antiviral activity of ribavirin. J. Biol. Chem. 276 (49):46094.Lanford et al. (2001) Ribavirin induces error-prone replication of GB virus B in primary tamarin hepatocytes. J. Virol. 75 (17):8074.Crotty et al. (2000) The broad-spectrum antiviral ribonucleoside ribavirin is an RNA virus mutagen. Nat. Med. 6 (12):1375.Ulrich et al. (2000) Towards the engineering of an orthogonal protein kinase/nucleotide triphosphate pair. Tetrahedron 56 (48):9495.Hong et al. (1999) Direct antiviral activity of ribavirin: Hepatitis C virus NS5B polymerase incorporates ribavirin triphosphate into nascent RNA products. Hepatology 30 (4):773 Part 2 Suppl. S.Jarvis et al. (1998) Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)- nucleoside transporters. Brit. J. Pharmacol. 123 (8):1587.Hosoya et al. (1993) Comparative inhibitory effects of various nucleoside and nonnucleoside analogs on replication of influenza-virus type-A and type-B in-vitro and inovo. J. Infect. Dis. 168 (3):641.Wray et al. (1985) Effect of ribavirin triphosphate on primer generation and elongation during influenza-virus transcription invitro. Antivir. Res. 5 (1):39.Eriksson et al. (1977) Inhibition of influenza-virus ribonucleic-acid polymerase by ribavirin triphosphate. Antimicrob. Agents Ch. 11 (6):946.