AP4U

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Validade: 12 months after date of delivery

Fórmula molecular: C19H27N7O21P4 (free acid)

Peso molecular: 813.35 g/mol (free acid)

CAS#: 10527-48-7

Pureza: ≥ 95 % (HPLC)

Forma: solution in water

Concentração: 10 mM - 11 mM

pH: 7.5 ±0.5

Propriedades espectroscópicas: λmax 260 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Formulários:
Synthesis by mutated enzyme H96G-Fhit^[1]
Formation by UTP-glucose-1-phosphate uridyltransferase^[2]
Synthesis by pyrococcus furiosus DNA ligase^[3]
TUNEL^[3]
Effector of Phosphotransferase^[4]
Inhibitor of Uridine Kinase^[5]
Vasoregulator through P2X₁, P2Y₂ and P2Y₄ receptors^[6]

Referências selecionadas:
[1] Huang et al. (2004) Engineering human Fhit, a diadenosine triphosphate hydrolase, into an efficient dinucleoside polyphosphate synthase. J. Am. Chem. Soc. 126 (31):9548.

[2] Guranowski et al. (2004) Uridine 5'-polyphosphates (p4U and p5U) and uridine (5')polyphospho (5')nucleosides (Up (n)Ns) can be synthesized by UTP:glucose-1-phosphate uridylyltransferase from Saccharomyces cerevisiae. FEBS Lett. 561 (1-3):83.

[3] Günther et al. (2002) Thermostable Pyrococcus furiosus DNA lgase catalyzes the synthesis of (di)nucleoside polyphosphates. Extremophiles 6 (1):45.

[4] Marques et al. (1998) IMP-GMP 5'-nucleotidase from rat brain: activation by polyphosphates. J. Neurochem. 71 (3):1241.

[5] Cheng et al. (1986) Homogeneous uridine kinase from Ehrlich ascites tumor: substrate specificity and inhibition by bisubstrate analogs. Mol. Pharmacol. 30 (2):159.

[6] Jankowski et al. (2005) Uridine adenosine tetraphosphate: a novel endothelium- derived vasoconstrictive factor. Nature Medicine 11 (2):223.