AP6A

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Validade: 12 months after date of delivery

Fórmula molecular: C20H30N10O25P6 (free acid)

Peso molecular: 996.35 g/mol (free acid)

CAS#: 56983-23-4

Pureza: ≥ 95 % (HPLC)

Forma: solution in water

Concentração: 10 mM - 11 mM

pH: 7.5 ±0.5

Propriedades espectroscópicas: λmax 259 nm, ε 27.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Formulários:
Kinetic parameters with arabidopsis thaliana Nudix hydrolase^[1]
Action as neurotransmitter^[2]
Modeling of binding to Nudix hydrolase Ndx1^[3]
Mediated release of atrial atriopeptin (ANP)^[4]

Specific Ligands:

Binding properties to Nudix hydrolase[5]

Referências selecionadas:
[1] Olejnik et al. (2007) Cloning and characterization of AtNUDT13, a novel mitochondrial Arabidopsis thaliana Nudix hydrolase specific for long-chain diadenosine polyphosphates. FEBS J. 274 (18):4877.

[2] Delicado et al. (2006) Dinucleoside polyphosphates and their interaction with other nucleotide signaling pathways. Pflugers Arch. 452 (5):563.

[3] Zheng et al. (2005)Homology modeling and substrate binding study of Nudix hydrolase Ndx1 from Thermos thermophilus HB8. Biochem. Biophys. Res. Commun. 333 (3):881.

[4] Yuan et al. (2007) Diadenosine tetraphosphate stimulates atrial ANP release via A (1) receptor: involvement of K (ATP) channel and PKC. Peptides 28 (7):1397.

[5] Garza et al. (2009) Kinetic, dynamic, ligand binding properties, and structural models of a dual-substrate specific nudix hydrolase from Schizosaccharomyces pombe. Biochemistry 48 (26):6224.

Gross et al. (2006) Nucleotide-binding domains of Cystic Fibrosis Transmembrane Conductance Regulator, an ABC Transporter, Catalyze Adenylate Kinase Activity but not ATP Hydrolysis. J. Biol. Chem. 281 (7):4058.

Luo et al. (1999) Identification of diadenosine hexaphosphate in human erythrocytes. Hypertension 34:872.

Van der Giet et al. (1999) Evidence for two different P2X-receptors mediating vasoconstriction of Ap5A and Ap6A in the isolated perfused rat kidney. Br. J. Pharmacol. 127:1463.

Fontes et al. (1999) Acyl-CoA synthetase catalyzes the synthesis of diadenosine hexaphosphate (Ap6A). Biochimie 81:229.

Schluter et al. (1994) Diadenosine phosphates and the physiological control of blood pressure. Nature 367:186.

Morii et al. (1992) Adenosine (5')hexaphospho (5')adenosine stimulation of a Ca (2+)-induced Ca (2+)-release channel from skeletal muscle sarcoplasmic reticulum. Eur. J. Biochem. 205:979.