2',3'-cGAMP
cyclic-[G(2',5')pA(3',5')p]
Cyclic-(guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate), Sodium salt
| Catálogo Nº | Apresentação | Preço (R$) | Comprar |
|---|---|---|---|
| NU-249S | 1 μmol | Sob demanda | Adicionar ao Carrinho |
| NU-249L | 5 x 1 μmol | Sob demanda | Adicionar ao Carrinho |
![Structural formula of 2',3'-cGAMP (cyclic-[G(2',5')pA(3',5')p], Cyclic-(guanosine-(2'→5')-monophosphate-adenosine-(3'→5')-monophosphate), Sodium salt)](/images/Structures/NU-249.png)
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C20H24N10O13P2 (free acid)
Peso molecular: 674.42 g/mol (free acid)
Pureza: ≥ 95 % (HPLC)
Forma: solid
Propriedades espectroscópicas: λmax 260 nm, ε 25.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Referências selecionadas:
Li et al. (2018) The cGAS–cGAMP–STING pathway connects DNA damage to inflammation, senescence, and cancer. J. Exp. Med. 215 (5):1287.
Li et al. (2016) Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response. Nature Scientific Reports 6:19049.
Tao et al. (2016) cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling. IUBMB Life 68 (11):858.
Temizoz et al. (2015) TLR9 and STING agonists synergistically induce innate and adaptive type-II IFN. Eur. J. Immunol. 45:1159.