5-Aza-dCTP
Decitabine triphosphate
5-Aza-2'-deoxycytidine-5'-triphosphate, Sodium salt
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| NU-1118 | 20 mg | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C8H15N4O13P3 (free acid)
Peso molecular: 468.14 g/mol (free acid)
CAS#: 72052-96-1
Pureza: ≥ 95 % (HPLC)
Forma: solid
Propriedades espectroscópicas: λmax 244 nm, ε 7.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Formulários:
Determination of methyltransferase activity[1]
Descrição:
5-Aza-dCTP is a inhibitor of DNA methylation and an antileukemic agent. It has been used to reactivate silent tumor suppressor genes.
Specific Ligands:
DNA-binding[1]
Please note:
1.) Contains at least 10 mg product
2.) The triazine moiety of decitabine is prone to acid- and base-catalyzed decomposition.[2] Always prepare a fresh solution for immediate use. Neutral buffers and low temperatures are most appropriate.
Referências selecionadas:
[1] Frauer et al. (2009) A versatile non-radioactive assay for DNA methyltransferase activity and DNA binding. Nucleic Acids Research 37 (3):e22.
[2] Lin et al. (1981) High-performance liquid chromatographic analysis of chemical stability of 5-aza-2'-deoxycytidine J. Pharm. Sci. 70 (11):1228.
Lemaire et al. (2005) Enhancement of antineoplastic action of 5-aza-2'-deoxycytidine by zebularine on L1210 leukemia. Anticancer Drugs. 16 (3):301.
Parker et al. (1987) Inhibition of DNA primase by nucleoside triphosphates and their arabinofuranosyl analogs. Mol. Pharmacol. 31 (2):146.
McIntosh et al. (1985) Synthesis and characterization of poly[d (G-z5C)]. B-Z transition and inhibition of DNA methylase. Biochemistry 24 (18):4806.
Momparler et al. (1984) Kinetic interaction of 5-AZA-2'-deoxycytidine-5'-monophosphate and its 5'-triphosphate with deoxycytidylate deaminase. Mol. Pharmacol. 25 (3):436.
Bouchard et al. (1983) Incorporation of 5-Aza-2'-deoxycytidine-5'-triphosphate into DNA. Interactions with mammalian DNA polymerase alpha and DNA methylase. Mol. Pharmacol. 24 (1):109.
Bouchard et al. (1983) Incorporation of 5-Aza-2'-deoxycytidine-5'-triphosphate into DNA. Interactions with mammalian DNA polymerase alpha and DNA methylase. Mol. Pharmacology 24 (1):109.