8-Bromo-cAMP

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Validade: 12 months after date of delivery

Fórmula molecular: C10H11N5O6PBr (free acid)

Peso molecular: 408.10 g/mol (free acid)

CAS#: 76939-46-3

Pureza: ≥ 95 % (HPLC)

Forma: solid

Propriedades espectroscópicas: λmax 264 nm, ε 17.0 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Referências selecionadas:
Paz et al. (1999) Corticotropin increases protein tyrosine phosphatase activity by a cAMP-dependent mechanism in rat adrenal gland. Eur. J. Biochem. 265:911.

Martin et al. (1999) Comparison of expression and regulation of the high-density lipoprotein receptor SR-BI and the lowdensity lipoprotein receptor in human adrenocortical carcinoma NCI-H295 cells. Eur. J. Biochem. 261:481.

Chen et al. (1998) Up-regulation of the cAMP/PKA pathway inhibits proliferation, induces differentiation, and leads to apoptosis in malignant gliomas. Lab. Invest. 78:165.

Hei et al. (1991) Lack of correlation between activation of cyclic AMP-dependent protein kinase and inhibition of contraction of rat vas deferens by cyclic AMP analogs. Mol. Pharmacol. 39:233.

Malgaroli et al. (1989) Control of cytosolic free calcium in rat and chicken osteoclasts. The role of extracellular calcium and calcitonin. J. Biol. Chem. 264:14342.

Schubart et al. (1977) Cyclic adenosine 3':5'-monophosphate-mediated insulin secretion and ribosomal protein phosphorylation in a hamster islet cell tumor. J. Biol. Chem. 252:92.

Martin et al. (1981) Growth inhibition by adenosine 3',5-monophosphate derivatives does not require 3',5' phosphodiester linkage. Science 213:1120.

Meyer et al. (1974) Analogs of cyclic AMP and cyclic GMP: general methods of synthesis and the relationship of structure to enzymic activity. Life Sci. 14:1019.