cIMP

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Validade: 12 months after date of delivery

Fórmula molecular: C10H11N4O7P (free acid)

Peso molecular: 330.19 g/mol (free acid)

CAS#: 41092-64-2

Pureza: ≥ 95 % (HPLC)

Forma: solution in water

Concentração: 10 mM - 11 mM

pH: 7.5 ±0.5

Propriedades espectroscópicas: λmax 249 nm, ε 12.2 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Referências selecionadas:
Wang et al. (2000) RNA polymerase-cNMP-ligated cAMP receptor protein (CRP) mutant interactions in the enhancement of transcription by CRP mutants. J. Biol. Chem. 275 (43):33457.

Shapiro et al. (2000) Structural basis for ligand selectivity of heteromeric olfactory cyclic nucleotide-gated channels. Biophys. J. 78 (5):2307.

Sunderman et al. (1999) Sequence of events underlying the allosteric transition of rod cyclic nucleotide-gated channels. J. Gen. Physiol. 113 (5):621.

Boadu et al. (1997) Binding characterization of a putative cGMP transporter in the cell membrane of human erythrocytes. Biochemistry-US 36 (36):10954.

Celeste et al. (1997) Identification of Critical Determinants for Autoinhibition in the Pseudosubstrate Region of Type Ia cAMP-dependent Protein Kinase. J. Biol. Chem. 272 (1):379.

Foster et al. (1996) Biochemical properties and cellular localization of the Drosophila DG1 cGMP-dependent protein kinase. J. Biol. Chem. 271 (38):23322.

Varnum et al. (1996) Subunit interactions in the activation of cyclic nucleotide-gated ion channels. Biophys. J. 70 (6):2667.

Reale et al. (1994) Nucleotide regulation of a calcium-activated cation channel in the rat insulinoma cell-line, CRI-G1. J. Membrane Biol. 141 (2):101.

Reddy (1978) Evidence for cyclic IMP as intracellular mediator of insulin action. Diabetes 27:499, Suppl. 2.

Agarwal et al. (1978) Effect of cyclic-GMP (cGMP) and cyclic IMP (cIMP) analogs on human platelet aggregation. Fed. Proc. 37 (3):546.