RCC1 (RanGEF)
Regulator of Chromosome Condensation, Ran Guanine Exchange Factor
human, recombinant, E. coli
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| PR-306 | 50 μg | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on dry ice
Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles
Validade: 12 months
Peso molecular: 44.97 kDa (421 amino acids)
Número de acesso: BC010067
Número de acesso: BC010067
Pureza: > 90 % (SDS-PAGE)
Forma: liquid (Supplied in 20 mM HEPES pH 7.6, 50 mM NaCl and 2 mM DTE)
Descrição:
RCC1 (Regulator of Chromosome Condensation, a β propeller chromatin-bound protein) catalyzes guanine nucleotide exchange of the Ras-related nuclear protein Ran. RCC1 is the guanine nucleotide exchange factor (GEF) for Ran which induces exchange between the bound GDP and cellular GTP. Genetic studies have suggested that RCC1 may be involved in sensing the replication state of DNA and controlling the activation of Cdc2/cyclin B protein kinase through Ran.
Referências selecionadas:
Renault et al. (2001) Structural Basis for Guanine Nucleotide Exchange on Ran by the regulator of Chromosome Condensation (RCC1). Cell 105:245. Clarke et al. (1995) Regulation of Cdc2/cyclin B activation by Ran, a Ras-related GTPase. J. Cell Sci. 108:1217. Bischoff and Ponstingl (1991) Catalysis of guanine nucleotide exchange on Ran by the mitotic regulator RCC1. Nature 354:80.