Rab18AGST-His
Ras-associated, small GTP-binding protein
mouse, recombinant, E. coli
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| PR-188 | 50 μg | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on dry ice
Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles
Validade: 12 months
Número de acesso: NP_035355
Número de acesso: NP_035355
Pureza: > 90 % (SDS-PAGE)
Forma: liquid (Supplied in 50 mM Tris-HCl pH 8.0, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP and 2 mM mercaptoethanol)
Atividade: 100 pmol of protein can bind > 80 pmol of GDP.
Descrição:
Rab18A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. Rab18A is localized in dense apical tubules (kidney) and basolateral membrane (intestine) as well as lipid droplets in ER and neuroendocrine secretory granules. The enzyme is involved in the formation of lipid droplets form ER. Furthermore it is a negative regulator of neuroendocrine secretion. The GST-Tag facilitates the protein`s application in typical GST pull-down assays.
Referências selecionadas:
Stenmark et al. (2001) The Rab GTPase family. Genome Biol. 2:30071. Yamaguchi et al. (2002) A GDP/GTP exchange protein for the Rab3 small G protein family up-regulates a postdocking step of synaptic exocytosis in central synapses. Proc. Natl. Acad. Sci. USA. 99:14536.