Rab17GST-His
Ras-associated, small GTP-binding protein
mouse, recombinant, E. coli
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| PR-118 | 50 μg | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on dry ice
Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles
Validade: 12 months
Peso molecular: 52 kDa
Número de acesso: NM_008998
Número de acesso: NM_008998
Pureza: > 90 % (SDS-PAGE)
Forma: liquid (Supplied in 25 mM HEPES pH 7.2, 40 mM NaCl, 2 mM MgCl2, 10 μM GDP and 3 mM DTE)
Atividade: 100 pmol of protein can bind > 80 pmol of GDP.
Descrição:
Rab17 is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The small GTPase Rab17 is restricted to epithelial cells and its expression is induced during cell polarization. In addition to the network of ubiquitous Rab GTPases, a set of epithelia-specific Rab proteins, including Rab17, Rab18, Rab20, and Rab25, facilitates endocytic and transcytotic transport to the apical and basolateral plasma membranes. The GST-Tag facilitates the protein`s application in typical GST pull-down assays.
Referências selecionadas:
Stenmark et al. (2001) The Rab GTPase family. Genome Biol. 2:30071. Somsel et al. (2000) Rab GTPases coordinate endocytosis. J. Cell Sci. 113:183. Hunziker et al. (1998) Rab17 Localizes to Recycling Endosomes and Regulates Receptor-mediated Transcytosis in Epithelial Cells. J. Biol. Chem. 273:15734.