Rab4A
Ras-associated, small GTP-binding protein
human, recombinant, E. coli
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| PR-117 | 50 μg | Sob demanda | Adicionar ao Carrinho |
For in vitro use only!
Envio: shipped on dry ice
Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles
Validade: 12 months
Número de acesso: NM_004578
Número de acesso: NM_004578
Pureza: > 90 % (SDS-PAGE)
Forma: liquid (Supplied in 25 mM HEPES pH 7.2, 100 mM NaCl, 10 mM MgCl2, 10 μM GDP and 2 mM DTE)
Atividade: 100 pmol of protein can bind > 80 pmol of GDP.
Descrição:
Rab4A is a small GTPase that belongs to the Ras superfamily. Rab proteins play an important role in various aspects of membrane traffic, including cargo selection, vesicle budding, vesicle motility, tethering, docking, and fusion. The monomeric GTPase Rab4 is associated with early endosomes and regulates recycling vesicle formation. Together with Rab5 it act to control influx and efflux out of early endosomes.
Referências selecionadas:
Chamberlain et al. (2008) Disrupted RabGAP Function of the p85 Subunit of Phosphatidylinositol 3-Kinase Results in Cell Transformation. J. Biol. Chem. 283:15861.
Stenmark et al. (2001) The Rab GTPase family. Genome Biol. 2:30071.
Mohrmann et al. (2002) Rab4 function in membrane recycling from early endosomes depends on a membrane to cytoplasm cycle. J. Biol. Chem. 277:32029.
Somsel et al. (2000) Rab GTPases coordinate endocytosis. J. Cell Sci. 113:183.
Chamberlain et al. (2004) The p85alpha Subunit of Phosphatidylinositol 3-Kinase Binds to and Stimulates the GTPase Activity of Rab Proteins. J. Biol. Chem. 279 (47):48607.