Rab6A

For general laboratory use.

Envio: shipped on dry ice

Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles

Validade: 12 months

Peso molecular: 23.6 kDa

Número de acesso: AF498939

Número de acesso: AF498939

Pureza: > 90 % (SDS-PAGE)

Forma: liquid (Supplied in 40 mM TRIS pH 7.2, 1 mM MgCl2, 40 mM NaCl, 20 μM GDP, 5 mM DTT)

Atividade: 100 pmol of protein can bind > 80 pmol of GDP.

Descrição:
Rab6A is a small GTPase that belongs to the Ras superfamily. It mediates intra-Golgi vesicular trafficking and is geranylgeranylated on both C-terminal cysteines.

Amino Acid Sequence: MSTGGDFGNP LRKFKLVFLG EQSVGKTSLI TRFMYDSFDN TYQATIGIDF LSKTMYLEDR TVRLQLWDTA GQERFRSLIP SYIRDSTVAV VVYDITNVNS FQQTTKWIDD VRTERGSDVI IMLVGNKTDL ADKRQVSIEE GERKAKELNV MFIETSAKAG YNVKQLFRRV AAALPGMEST
QDRSREDMID IKLEKPQEQP VSEGGCSC

Referências selecionadas:
Feldmann et al. (1995) Behaviour of the small GTP-binding protein rab6 in the liver of normal rats and rats presenting an acute inflammatory reaction. Biol. Cell 83:121.

Beranger et al. (1994) The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization. Mol. Cell. Biol. 14:744.

Chamberlain et al. (2004) The p85alpha Subunit of Phosphatidylinositol 3'-Kinase Binds to and Stimulates the GTPase Activity of Rab Proteins. J. Biol. Chem. 279 (47):48607.