Rab7
Ras-associated, small GTP-binding protein
dog, recombinant, E. coli
| Catálogo Nº | Apresentação | Preço (R$) | Comprar / Observação |
|---|---|---|---|
| PR-108 | 50 μg | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on dry ice
Condições de armazenamento: store at -80 °C
avoid freeze/thaw cycles
Validade: 12 months
Peso molecular: 23.5 kDa
Número de acesso: NM_001003316
Número de acesso: NM_001003316
Pureza: > 90 % (SDS-PAGE)
Forma: liquid (Supplied in 25 mM HEPES pH 7.2, 40 mM NaCl, 5 mM DTT, 2 mM MgCl2 and 10 μM GDP)
Atividade: GTPγS binding: >750 mmol/mol.
Descrição:
Rab7 is a 23.5 kDa small GTPase localized in late endosomes. Rab7 regulates late endocytic membrane traffic between endosomes and lysosomes. The protein contains a C-terminal CXC motif for post-translational geranylgeranylation.
Referências selecionadas:
Vitelli et al. (1997) Role of the small GTPase RAB7 in the late endocytic pathway. J. Biol. Chem. 272:4391. Bottger et al. (1996) Rab4 and Rab7 define distinct nonoverlapping endosomal compartments. J. Biol. Chem. 271:29191. Chavrier et al. (1990) Localization of low-molecular-weight GTP binding-proteins to exocytic and endocytic compartments. Cell 62:317. Watanabe et al. (2008) Inhibitors of Protein Geranylgeranyltransferase I and Rab Geranylgeranyltransferase Identified from a Library of Allenoate-derived Compounds. J. Biol. Chem. 283 (15):9571-9579.