Guanosine-3',5'-pentaphosphat
(pppGpp)
Guanosine-3'-diphosphate-5'-triphosphate, Lithium salt
| Catálogo Nº | Apresentação | Preço (R$) | Comprar |
|---|---|---|---|
| NU-885S | 10 μl (100 mM) | Sob demanda | Adicionar ao Carrinho |
| NU-885L | 5 x 10 μl (100 mM) | Sob demanda | Adicionar ao Carrinho |
For general laboratory use.
Envio: shipped on gel packs
Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.
Validade: 12 months after date of delivery
Fórmula molecular: C10H18N5O20P5 (free acid)
Peso molecular: 683.14 g/mol (free acid)
Pureza: ≥ 85 % (HPLC)
Forma: solution in water
Concentração: 100 mM - 110 mM
pH: 7.5 ±0.5
Propriedades espectroscópicas: λmax 252 nm, ε 13.6 L mmol-1 cm-1 (Tris-HCl pH 7.5)
Descrição:
(p)ppGpp (collective for ppGpp and pppGpp) is a nucleotide based second messenger and a key regulator of stringent stress response in many bacteria[1]. During nutritional starvation (p)ppGpp initiates the switch from bacterial growth into survival mode. Growth is arrested as (p)ppGpp binds RNA polymerase (RNAP) leading to repressed transcription rate of stable RNA (rRNA, tRNA). Instead, transcription of genes involved in biosynthesis of amino acids is enhanced, leading to prolonged survival[2].
Produtos relacionados: ppGpp, #NU-884
Referências selecionadas:
[1] Hauryliuk et al. (2015) Recent functional insights into the role of (p)ppGpp in bacterial physiology. Nature Reviews Microbiology.
[2] Dalebroux et al. (2012) ppGpp: magic beyond RNA polymerase. Nature Reviews Microbiology 10 (3):203.