2-Thio-UTP

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Validade: 12 months after date of delivery

Fórmula molecular: C9H15N2O14P3S (free acid)

Peso molecular: 500.21 g/mol (free acid)

CAS#: 35763-29-2

Pureza: ≥ 95 % (HPLC)

Forma: solution in water

Concentração: 100 mM - 110 mM

pH: 7.5 ±0.5

Propriedades espectroscópicas: λmax 274 nm, ε 14.2 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Specific Ligands:

Ligand for purinergic receptors:
Potent and selective agonist at P2Y2 receptor and [1,2,3,4]

Produtos relacionados: HighYield T7 RNA Synthesis Kit, #RNT-101

Referências selecionadas:
[1] Higgins et al. (2014) Nucleotides Regulate Secretion of the Inflammatory Chemokine CCL2 from Human Macrophages and Monocytes. Mediators Inflamm. 293925.

[2] Zizzo M. et al. (2012) Pharmacological characterization of uracil nucleotide-preferring P2Y receptors modulating intestinal motility: a study on mouse ileum. Purinergic Signal. 8 (2):275.

[3] Ko et al. (2008) Synthesis and potency of novel uracil nucleotides and derivatives as P2Y2 and P2Y6 receptor agonists. Bioorg. Med. Chem. 16 (12):6319.

[4] El-Tayeb et al. (2006) Synthesis and structure-activity relationships of uracil nucleotide derivatives and analogues as agonists at human P2Y2, P2Y4, and P2Y6 receptors. J. Med. Chem. 49 (24):7076.

Kormann et al. (2011) Expression of therapeutic proteins after delivery of chemically modified mRNA in mice. Nature Biotechnology 29:154.

Warren et al. (2010) Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell 7 (5):618.