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  6. 8-Oxo-GTP

8-Oxo-GTP

8-Hydroxy-GTP

8-Oxo-guanosine-5'-triphosphate, Sodium salt

8-Hydroxy-guanosine-5'-triphosphate, Sodium salt

Datasheet (PDF)
Catálogo Nº Apresentação Preço (R$) Comprar
NU-1116S 50 μl (10 mM)Sob demanda Adicionar ao Carrinho
NU-1116L 5 x 50 μl (10 mM)Sob demanda Adicionar ao Carrinho
Structural formula of 8-Oxo-GTP (8-Hydroxy-GTP, 8-Oxo-guanosine-5'-triphosphate, Sodium salt)
Structural formula of 8-Oxo-GTP

For general laboratory use.

Envio: shipped on gel packs

Condições de armazenamento: store at -20 °C
Short term exposure (up to 1 week cumulative) to ambient temperature possible.

Validade: 12 months after date of delivery

Fórmula molecular: C10H16N5O15P3 (free acid)

Peso molecular: 539.18 g/mol (free acid)

CAS#: 21238-36-8

Pureza: ≥ 95 % (HPLC)

Forma: solution in water

Concentração: 10 mM - 11 mM

pH: 7.5 ±0.5

Propriedades espectroscópicas: λmax 245 nm, ε 12.3 L mmol-1 cm-1 (Tris-HCl pH 7.5)

Formulários:
Hydrolysis by arabidopsis Nudix hydrolase[1]
X-ray analysis of complex with GTP-cyclohydrolase I (GTPCH 1)[2]

Specific Ligands:

Binding to cancer-related PRUNE2[3]

Referências selecionadas:
[1] Yoshimura et al. (2007) AtNUDX1, an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis. Plant and Cell Physiology 48:1438.

[2] Tanaka et al. (2005) Novel reaction mechanism of GTP cyclohydrolase I. High-resolution X-ray crystallography of Thermus thermophilus HB8 enzyme complexed with a transition state analogue, the 8-oxoguanine derivative. J. Biochem. (Tokyo) 138 (3):263.

[3] Iwama et al. (2011) Cancer related PRUNE 2 protein is associated with nucleotides and is highly expressed in mature nerve tissues. J. Molecular Neuroscience 44:103.

Ramírez (2004) Gene of Bacillus subtilis Encodes a Functional Antimutator 8-Oxo- (dGTP/GTP)ase and Is under Dual Control of Sigma A and Sigma F RNA Polymerases. Journal of bacteriology 186 (4):1050.

Nakabeppu (2001) Molecular genetics and structural biology of human MutT homolog, MTH1. Mutat Res. 477 (1-2):59.

Kobayashi et al. (1998) Potential of Escherichia coli GTP cyclohydrolase II for hydrolyzing 8-oxo-dGTP, a mutagenic substrate for DNA synthesis. J. Biol. Chem. 273 (41):26394.

Kuryavyi et al. (1989) Kinetics of inhibition of escherichia-coli RNA polymerase-catalyzed synthesis of the dinucleotide pppApU by 8-oxo-GTP and 8-BrGTP on the A1 promoter of Bacteriophage-t7 delta-d111 DNA using a limited set of substrates. Mol. Biol. 23 (3):648.