Na-Ascorbate - click chemistry grade

For general laboratory use.

Envio: shipped at ambient temperature

Condições de armazenamento: store at ambient temperature
store dry

Validade: 12 months after date of delivery

Fórmula molecular: C6H7NaO6

Peso molecular: 198.11 g/mol

CAS#: 134-03-2

Pureza: ≥ 98 % (TLC)

Forma: solid

Solubilidade: water

Descrição:
Na-Ascorbate can be used as a reduction reagent for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC).

It catalyzes the reduction of Cu(II) sources such as CuSO4 thereby releasing catalytically reactive Cu(I) ions.

Ideally, solutions should be freshly prepared in ddH2O shortly before use. Alternatively, a stock solution can be prepared, stored at -20°C and freshly by diluted shortly before use.

Please note: Do not use solutions that appear brown. Freshly prepared, fully functional Na-Ascorbate solutions are colorless and turn brown upon oxidization thereby loosing their reduction capability.

Presolski et al.[1] and Hong et al.[2] provide a general protocol for CuAAC reactions that may be used as a starting point for the set up and optimization of individual assays.

Produtos relacionados:

• Copper (II)-Sulphate (CuSO4), #CLK-MI004
• THPTA, #CLK-1010
• BTTAA, #CLK-067

Referências selecionadas:
[1] Presolski et al. (2011) Copper-Catalyzed Azide-Alkyne Click Chemistry for Bioconjugation. Current Protocols in Chemical Biology 3:153.
[2] Hong et al. (2011) Analysis and Optimization of Copper-Catalyzed Azide-Alkyne Cycloaddition for Bioconjugation. Angew. Chem. Int. Ed. 48:9879.